Que penser du coronavirus ?

@bibimet75

Mais inscrivez-vous sur Medscape, c’est gratuit. .

@Mini423

ce variant correspond à un variant dit « anglais « , présent depuis mi-janvier en France, donc, à priori, très contagieux et pas trop pathogène. .

Bon et rapide très rapide rétablissement . .

@bibimet75

Le texte souche :

Valneva COVID-19 vaccine: What do we know about it?

Written by Katharine Lang on April 28, 2022 — Fact checked by Rita Ponce, Ph.D.

VLA2001, a new COVID-19 vaccine developed by Valneva, a French biotechnology company, using traditional methods, has now received conditional marketing authorization in the United Kingdom. Could it prove more acceptable to the vaccine hesitant, be more effective against new variants, or improve the situation in low-income countries? Medical News Today looks at the evidence.

Share on PinterestWhat is there to know about Valneva, the new COVID-19 vaccine approved in the United Kingdom? Image credit: Ayman Yaqoob/Anadolu Agency via Getty Images.

With more than 6.2 million deaths and close to 510 million cases confirmed worldwide by the World Health Organization (WHO), COVID-19 has wrought a heavy toll.In high-income countries, such as the United StatesTrusted Source and the United KingdomTrusted Source, although case rates remain high, vaccination has been effective in reducing hospitalizations and deaths.Around the world, COVID-19 vaccines have been and are being authorized. Across European countries, five vaccines have gained use authorization: Pfizer, Moderna, Oxford-AstraZeneca, Johnson & Johnson (Janssen), and Novavax.In the U.S.Trusted Source, Pfizer, Moderna, and Johnson & Johnson have so far received authorization or approval for use.Now, the U.K. Medicines Regulatory and Healthcare Products Regulatory Agency (MHRA) has granted regulatory approval for the use of a new COVID-19 vaccine, developed by the French biotechnology company Valneva.

The vaccine

This vaccine, VLA2001, uses a method that may be considered more traditionalTrusted Source — an inactivated virusTrusted Source — as used in vaccines for polio, hepatitis A, rabies, and influenza.Valneva, like other COVID-19 vaccines such as Sinopharm, uses inactivated whole virus particles of SARS-CoV-2, as well as adjuvant substances.An inactivated virus cannot replicate and cause disease, but exposure to the inactivated viral particles in the vaccine allows the body’s immune system to learn to recognize and react to the virusTrusted Source that causes COVID-19, as it happens with other types of vaccines.The MHRA granted conditional marketing authorization for the Valneva vaccine on April 14, 2022, for adults aged 18-50 — the first European country to do so.Bahrain gave it emergency use authorization in March, and the vaccine is undergoing regulatory review by the European Medicines Agency (EMA).

Similar efficacy

Some phase 1 and 2 trials and one phase 3 trial have been completed, but the results have yet to be peer-reviewed. The MHRA approved the vaccine on immunobridging data — data measuring immune markers to infer vaccine efficacy — rather than results of clinical trials in volunteers.The phase 1/2 trial whose data has been published had only 153 participants, but the results were encouraging. Participants experienced only mild side effects — localized tenderness and soreness at the injection site, headache, or fatigue in around half of the recipients — and immune responses were good.Valneva has reported immune responses comparable to existing vaccines and few side effects in its phase 3 trial, which involved 4,012 participants.Prof. William Schaffner, professor of infectious diseases at the Vanderbilt University School of Medicine in Nashville, TN, told Medical News Today he was nevertheless cautious about the new vaccine:

“There are some other protein-based whole-cell-like vaccines that have been made in the traditional way, such as the Chinese vaccine [Sinopharm], that, although they are effective, haven’t been quite as effective as the mRNA vaccines. So we’ll have to see.”

Potential benefits

The five already-authorized vaccines have been effective in reducing the toll of COVID-19, so what does this new vaccine add?Some people are hesitant about the existing COVID-19 vaccines because of their rapid development and especially the new mRNA technologies used in the Pfizer and Moderna vaccines.Because Valneva uses inactivated whole-virus particles, in common with many familiar vaccines, might people be more willing to accept it?

“It might attract some [vaccine-hesitant] people because it is a very traditional technology, but I don’t think it will be, as we say in the U.S., a game-changer.”– Prof. William Schaffner

High-income countries already have a good vaccination coverage, so it is unlikely to make a great difference there. However, the Valneva vaccine has one big advantage over the mRNA vaccines.It can be transported easily and stored at normal fridge temperatures, which could help worldwide vaccine rollout, as Prof. Schaffner confirmed.“Even in [low-income] countries they have cold chains that are used to these temperatures, which would make it much more readily transportable in challenging environments,” he told us.

More effective against variants?

Some experts have suggested that a vaccine using the whole virus may be more effective against new variants, as Prof. Eleanor Riley, professor of immunology and infectious disease at the University of Edinburgh, notes:

“One particular advantage of the Valneva vaccine is that it is made up of the whole SARS-CoV-2 virus, not just the spike protein. This means that it will induce antibodies and T cell cells against many different components of the virus, including components that are much less susceptible to variation than the spike protein. It is possible, therefore, that this vaccine may provide better protection against new variants as they arise.”

‘Not a game-changer’

So, the Valneva vaccine is a useful addition to the armory of vaccines available against COVID-19, and could have a significant impact if licensed for use in low-income countries.But, even if the EMA approves it, it seems unlikely that this vaccine will be a game-changer in those countries that have already achieved a high level of vaccination.

3 x vacciné et je vis avec le covid

ce n'est pas un problème

et je ne suis pas mort grace à la vaccination !!

@maritima

même sans citer on a tous compris ou vous vouliez en venir @bibimet75

là ça fait 2 fois quand même !on ne vous a pas appris à ne pas parler des gens derrière leur dos !

je vais demander à Daniel (@ledalle ) ce qu'il pense de ça ! ah mais suis je bête vous allez lui envoyer un mp !!! 😡

Entre le prosélytisme anti vaccin et la propagande Valvena on se demande où on est là !

@chatdoc jai pathologie chronique et neurogie vessie et dos

- Tennis : Tournoi de Miami -

15 abandons lors des matchs de ce Tournoi.

Le monde du tennis a été choqué de voir comment deux des meilleurs joueurs de tennis du monde, l'Ibérique Paula Badosa et l'Italien Jannik Sinner, ont abandonné les matchs qu'ils ont disputés lors du tournoi de Miami.

Les non vaccinés mettent en danger les vaccinés . .

« lorsque les vaccinés ne sont pas exposés au non-vaccinés, leur risque est très bas », indiquent les auteurs.

"Ce qui signifie que le refus du vaccin a un impact non négligeable sur la santé publique et la santé individuelle d’autrui.

« On ne peut donc pas avancer l’argument du choix individuel sans impact autre que sur soi », concluent-ils."

@Alain08 comme vous le dites souvent : cela pose question.

@Alain08

Vous êtes le roi de l'information qui date et qui a été démentie quant à l'interprétation qui vous convient.

Vous devriez penser à vérifier la qualité de vos sources, c'est presque trop facile de vous démentir !!

https://www.tf1info.fr/sante/tennis-la-cascade-d-abandons-lors-du-tournoi-de-miami-associee-de-maniere-trompeuses-aux-vaccins-contre-le-covid-19-2215633.html